Zoloft is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs), which works by balancing serotonin levels in the brain and nerves. Zoloft (sertraline) is an antidepressant that helps balance serotonin levels - a neurotransmitter responsible for emotional stability. It is used across multiple therapeutic settings due to its proven efficacy and low risk of dependence. Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings What is Zoloft? Zoloft is the brand name for sertraline, an antidepressant medication. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Zoloft is a selective serotonin reuptake inhibitor (SSRI) used to treat depression and other conditions. Learn how Zoloft works, its side effects, and precautions. What is Zoloft? Zoloft is the brand name for sertraline, an antidepressant that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It's used to treat a list of mental health conditions, including anxiety and depression, by increasing serotonin levels in your brain. Sertraline (Zoloft) is a first-line SSRI for depression, OCD, PTSD, and anxiety. Learn dosing, side effects, real patient reviews, and global pricing. Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [11] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [12] Zoloft treats depression, anxiety, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD). Use our guide to learn more about Zoloft, how it works, and how to take it safely.